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Fall on the Mississippi River Trail

May 2025
SMTWTFS
May 2025
SMTWTFS

You may never have heard of the Mississippi River Trail, but we hope you put it on your “must-do” list this fall. The Mississippi River follows the Great River Road, winding alongside one of America’s most iconic waterways for over 3,000 miles. This trail is an epic bike ride in the making, offering an unparalleled way to experience the Midwest’s autumnal splendor. This extensive trail system spans multiple states and is renowned for its scenic vistas and the vibrant colors that transform the landscape each fall.

Let the crisp fall air invigorate your senses this autumn. Cyclists and hikers who take on stretches of the Mississippi River Trail are greeted with breathtaking views of the river. It’s a refreshing escape from the daily grind – but it’s a journey that’s about so much more than the trail alone. The Mississippi River Trail provides a deep connection to the region’s rich ecological and cultural heritage. The river is a lifeline for numerous wildlife species, and the trail allows for intimate encounters with the natural environment. Birdwatchers and nature enthusiasts will delight in the many opportunities to observe migratory birds and other wildlife in their autumn habitats. In contrast, others will enjoy exploring the quaint riverside towns you’ll encounter along the way. 

At the end of each day on the trail, a welcoming home away from home will be waiting for you. The Midwest Association of Independent Inns offers an array of top-tier lodging options across the Midwest, including in towns along the Mississippi River. These bed and breakfasts, inns, and boutique hotels provide a perfect respite after a day of exploring the Mississippi River Trail. With a focus on comfort, hospitality, and unique local charm, these Inns will enhance any fall getaway in the Midwest. Browse our Inns by availability, and enjoy some of the best places to stay in the Midwest this fall!

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Bike Along the Mississippi River Trail

The Mississippi River Trail, which runs along the famous Great River Road National Scenic Byway, is one of the longest bike trails in the Country. Starting at the headwaters of the Mississippi River in Minnesota’s Itasca State Park, the Trail follows the river for more than 3,000 miles, offering one of the country’s most scenic and epic bike rides. 

Most of the Mississippi River Trail is paved, with some parts using state recreational trails and others following scenic stretches of highway along the Great River Road. The trail’s diverse landscapes, ranging from dense forests to open prairies, provide a dynamic backdrop for fall excursions. 

Minnesota

Within Itasca State Park, you’ll find the modest headwaters of the Mighty Mississippi. It’s here that the Mississippi River Trail begins. From here, cyclists can network their way down over 800 miles of roads and trails known as U.S. Bicycle Route 45. As the trail continues south toward the border with Iowa, it passes through the Twin Cities of Minneapolis and St. Paul, where you’ll find even more urban biking paths, plenty of cultural attractions, and other things to do.

The entire journey through Minnesota will take you through varied terrain, including lush forests, open prairies, and communities big and small. The grade of Minnesota’s portion of the trail is generally flat, with only one steep section of the Apple Blossom Scenic Byway south of the Twin Cities. The majority of Minnesota’s Mississippi River Trail includes road shoulders, but there are also options to travel along segments of scenic state, regional, and local trails for a more relaxed experience. 

Wisconsin

On the other side of the Mississippi River Trail in Minnesota are the Wisconsin Trails that parallel many of the same stretches of the river. The 250 miles of trail wind along the river bluffs between Prescott and Prairie du Chien, providing breathtaking vistas of the Mississippi River below. Like in Minnesota, cyclists in Wisconsin will enjoy much of their ride on highways with broad bike shoulders. The big exception to this is the 24-mile section of the Great River State Trail.

The Great River Road in Wisconsin is lined with charming towns like La Crosse, where visitors can enjoy even more opportunities to explore the Mississippi River ecosystem while visiting local breweries and wineries, art galleries, superb dining, and so much more. This stretch of the Mississippi River Trail is also where you’ll find some of the best fall birdwatching opportunities at The Upper Mississippi River National Wildlife and Fish Refuge.

Iowa

As the Mississippi River Trail enters Iowa, it follows its meandering path through rolling hills and Iowa’s fertile farmlands. On one side of this stretch of the trail is Wisconsin’s Driftless area and popular river towns like Prairie du Chien, while on the other are Iowa’s river towns like Harpers Ferry and the Effigy Mounds National Monument, a Native American archaeological site with 14 mi. of trails. From there, the Mississippi River Trail in Iowa works its way south toward popular riverside towns like Dubuque and Clinton before finally ending at the Quad Cities of Riverdale, Bettendorf, Davenport, and Buffalo. 

Of the many highlights of Iowa’s portion of the Mississippi River Road is the climb to the top of the bluff at Pike’s Peak State Park. It offers one of the best views of the entire Mississippi River. 

Illinois

The beautiful riverside stretches of the Mississippi River Trail in Illinois are opposite the river towns of Iowa. Opposite Dubuque, near the charming and historic town of Galena, you’ll follow the Mississippi River as it passes through vibrant metropolitan areas like the Quad Cities and plenty of rural and serene landscapes of western Illinois. You’ll find countless opportunities to enjoy bluff-top views of the river, including at beautiful parks like Pere Marquette State Park in Grafton.

Near the Quad Cities, bikers can explore the Rock Island Arsenal, a historic military site, or enjoy riverfront parks and trails. At the southern stretch of this trail segment, don’t miss the climb to the top of Monk’s Mound at the Cahokia Mounds State Historic Site. This is the largest site of pre-Columbian settlement north of Mexico and is now a UNESCO World Heritage Site.

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Couple enjoying breakfast at one of the best places to stay in the Midwest

Discover the Best Places to Stay in the Midwest

While you enjoy epic fall adventures like biking on the Mississippi River Trail, you’ll also have the opportunity to discover some of the best places to stay in the Midwest. The properties belonging to the Midwest Association of Independent Inns stand out for their exceptional attention to detail and personalized service. Each inn offers a unique blend of local charm and modern amenities, ensuring that guests experience the true essence of Midwestern hospitality. From luxurious bed and breakfasts and boutique hotels to rural farm stays and intimate cabin getaways, these properties provide the perfect opportunity to stay and enjoy the distinct character of their locations.

The diverse selection of accommodations affiliated with Midwest Inns caters to a wide range of preferences and needs. Whether seeking a romantic getaway, a family vacation, or a solo retreat, these inns provide tailored experiences that enhance your travel. With locations in picturesque small towns and vibrant urban centers, guests can enjoy convenient access to local attractions, dining, and cultural activities. In short, you have easy access to the best of the Midwest at your fingertips.

In addition to their prime locations, our Midwest lodging partners are renowned for their commitment to quality and guest satisfaction. The innkeepers take pride in offering exceptional service, from gourmet breakfasts made with local ingredients to personalized recommendations for exploring the area. This dedication to excellence makes Midwest Inns the best places to stay in the Midwest. Don’t miss our unique and enriching lodging opportunities up and down the Mississippi River this fall. Book your getaway today!

Lodging Properties near topics in our blog

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Historic District Bed and Breakfast

  • 483 Ashland Avenue
    Saint Paul, Minnesota 55102
  • 763-360-3717
  • Email Us
A high value boutique inn with a gourmet breakfast and personal service in a unique and historic neighborhood. Close to museums, concert venues, small business owned restaurants and bars.
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Justin Trails Resort

  • 7452 Kathryn Avenue
    Sparta, Wisconsin 54656
  • 608-855-0282
  • Email Us
Offering pet-friendly eco-luxury lodging and surrounded by the Driftless Region’s Hidden Valleys, our 200-acre estate features diverse accommodations, sustainable practices, and elegant barn weddings.
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Cloran Mansion Bed & Breakfast

  • 1237 Franklin Street
    Galena, Illinois 61036
  • 815-777-0583
  • Email Us
Guests to the Cloran will find modern comfort surrounded by historic charm. Treat yourself to 21st-century amenities certain to pamper while taking in the beauty of 1800s Italianate architecture!
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Andor Wenneson, now The Wen Inn

  • 425 Prospect Street
    Peterson, Minnesota 55962
  • (507) 577-9691
  • Email Us
Constructed over a century ago, the Wen holds a unique charm that is perfectly molded within its extended history. Retaining original antiques from the 1900’s, you will be transported back in time.
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Hawk Valley Retreat & Cottages

  • 2752 West Cording Road
    Galena, Illinois 61036
  • 815-777-4100
  • Email Us
You are invited to relax, restore, and explore at our Galena Illinois Bed and Breakfast, a nature lover’s destination. We are located just 8 miles east of downtown Galena, IL.
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Round Barn Farm B&B and Event Center

  • 28650 Wildwood Lane
    Red Wing, Minnesota 55066
  • 952-292-9340
  • Email Us
We are a unique Minnesota Wedding Venue with a charming Bed & Breakfast in Red Wing, Minnesota. Deluxe Jacuzzi tubs and Franklin gas stoves. Enjoy 5 star luxury with your 3 course breakfast.
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The Three Elizabeths Guest House

  • 101 West Main Street
    Elizabeth, Illinois 61028
  • 815-990-8618
  • Email Us
Located 15 minutes East of Galena, accommodations include three Guest Rooms, classically styled, each with their own private bath. Reasonable rates and a welcoming front porch entice visitors.
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Como Lake Bed and Breakfast

  • 1205 West Como Boulevard
    Saint Paul, Minnesota 55103
  • 651-399-4111
  • Email Us
Classic Craftsman style Inn overlooking St Paul’s Como Lake and adjacent to the regional gem, Como Park.
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Fisher House Bed & Breakfast

  • 407 5th Avenue South
    Clinton, Iowa 52732
  • 563-249-8948
  • Email Us
A completely remodeled Queen Anne Victorian home that features 4 unique bedrooms each with a private bathroom. There are 2 rooms with queen size beds and 2 rooms with king size beds.
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Hotel Galena

  • 324 Spring Street
    Galena, Illinois 61036
  • 815-777-0123
  • Email Us
Located in historic downtown Galena, Hotel Galena offers a fabulous experience at an exceptional price. Boasting a 5* Google rating, it’s perfect for couples, families, groups, or solo travelers.
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The Midwest Association of Independent Inns was formed to help the discerning traveler find the best Bed and Breakfasts, Inns and Boutique Hotels. Our member properties are located throughout the Midwest with plans to welcome properties from all 13 Midwest states.

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